ABSTRACT
En el año 1899, en el viejo Hospital de Clínicas de Buenos Aires Eugenio Py filmó una intervención quirúrgica que practicó el Dr. Alejandro Posadas para resecar un quiste hidatídico de pulmón. En la película se ve a Posadas operando, y administrando la anestesia al Practicante Rodolfo S. Roccatagliata que tiene en su mano derecha un frasco, del cual deja caer esporádicamente un fármaco sobre una máscara anestésica. Es probable que la anestesia se realizó con el cloroformo y la máscara de Schimmelbusch. En las conclusiones, se considera que esta película testimonia que la primera filmación de una anestesia general en el mundo se hizo en Buenos Aires.
In 1899 at the old Hospital de Clínicas in Buenos Aires, Eugenio Py filmed a surgical procedure performed by Dr. Alejandro Posadas to extirpate a lung hydatid cyst. The film shows Posadas operating and Rodolfo S. Roccatagliata administering anesthesia, holding in his right hand a bottle from which he sporadically drops a drug to an anesthetic mask. It is probable that the anesthetic was chloroform, and the mask that of Schimmelbusch. The conclusion is that that this film is proof of being the first one of general anesthesia in the world, taken in Buenos Aires.
Em 1899, no velho Hospital de Clínicas de Buenos Aires, Eugenio Py filmou uma intervenção cirúrgica realizada pelo Dr. Alejandro Posadas para resseção de um cisto hidático de pulmão. No filme se vê ao Dr. Posadas operando e ao praticante Rodolfo S. Roccatagliata administrando a anestesia, quem tem um frasco na mão direita do qual cai, esporadicamente, um fármaco a uma máscara anestésica. É provável que o anestésico fosse o clorofórmio e a máscara, a de Schimmelbusch. Nas conclusões se considera que este filme é um testemunho de que a primeira filmagem de uma anestesia geral no mundo foi feita em Buenos Aires.
Subject(s)
Humans , Male , History, 19th Century , Anesthesiology/history , Chloroform/history , Echinococcosis, Pulmonary/surgery , Argentina , Chloroform/administration & dosage , History of Medicine , Physicians/historyABSTRACT
Miasis es la infestación de órganos o tejidos por larvas de moscas. La infestación con larvas de mosca produce diversas manifestaciones según el sitio afectado y puede incluso, causar la muerte. No es una enfermedad común en humanos pero se observa con alguna regularidad en países neotropicales. Afecta con mayor frecuencia las áreas expuestas de la piel y se presenta raramente en ojos, nariz, senos paranasales, tracto urogenital o recto; en estos casos la infestación se asocia con traumas previos o secresiones purulentas que atraen a las moscas adultas. Se presenta el caso de una paciente femenina de 65 años de edad, con prolapso total del útero (histerocele grado IV) complicado con miasis específica por Cochliomya hominivorax.
Subject(s)
Humans , Female , Aged , Abdominal Pain/diagnosis , Fever/diagnosis , Hysterectomy/methods , Screw Worm Infection/parasitology , Myiasis/classification , Myiasis/complications , Myiasis/diagnosis , Uterine Prolapse/surgery , Uterine Prolapse/pathology , Chloroform/administration & dosage , Genitalia, Female/injuries , Saline Solution, Hypertonic/administration & dosageABSTRACT
Chloroform and eucalyptol are widely used in clinical dentistry as gutta-percha solvents. However, these compounds may represent a hazard to human health, especially by causing injury to genetic apparatus and/or inducing cellular death. In this study, the genotoxic and cytotoxic potentials associated with exposure to chloroform and eucalyptol were assessed on mouse lymphoma cells in vitro by the single cell gel (comet) assay and trypan blue exclusion test, respectively. Both gutta-percha solvents proved to be cytotoxic at the same levels in concentrations of 2.5, 5 and 10 muL/mL (p<0.05). On the other hand, neither of the solvents induced DNA breakage. Taken together, these results suggest that although both tested compounds (chloroform and eucalyptol) are strong cytotoxicants, it seems that they are not likely to increase the level of DNA damage on mammalian cells.
Clorofórmio e eucaliptol são amplamente utilizados na clínica odontológica como solventes de guta-percha. Entretanto, estes compostos podem representar um perigo à saúde humana, especialmente por causar danos ao aparelho genético e/ou induzir morte celular. Neste estudo, o potencial genotóxico e citotóxico associado à exposição ao clorofórmio e eucaliptol foram avaliados em células de linfoma murino in vitro pelo teste de células individualizadas (teste do cometa) e pelo teste do azul de tripan, respectivamente. Ambos os solventes de guta-percha provaram ser citotóxicos nos mesmos níveis em concentrações de 2,5, 5 e 10 miL/mL (p<0.05). Por outro lado, nenhum dos dois solventes induziu danos ao DNA. Em conclusão, esses resultados sugerem que ambos os compostos testados (clorofórmio e eucaliptol) são potentes citotoxinas, mas não representam um fator que aumenta o nível de danos no DNA em células de mamíferos.
Subject(s)
Animals , Mice , Chloroform/toxicity , Cyclohexanols/toxicity , Eucalyptus , /pathology , Monoterpenes/toxicity , Solvents/toxicity , Comet Assay , Cell Survival/drug effects , Chloroform/administration & dosage , Coloring Agents , Cyclohexanols/administration & dosage , DNA , DNA Breaks , Gutta-Percha/chemistry , Monoterpenes/administration & dosage , Mutagens/toxicity , Solvents/administration & dosage , Trypan BlueABSTRACT
Pain associated with Herpes Zoster (HZ) and Post-herpetic Neuralgia (PHN) has been a challenging task to manage with ease. Topical aspirin dissolved in chloroform is an effective means of reducing pain due to HZ and PHN in most patients. The locus of pain origin and analgesia induced by topical aspirin is supposed to be at cutaneous free nerve ending pain receptors. The present study was conduced in fifty two patients of HZ and PHN. Pain intensity before and after the application of drug was measured with help of Sort Form McGill Pain Questionnaire (SE-MPQ). Most of the patients experienced relief of pain within 1-5 minutes after the aspirin-chloroform application. Maximum relief was achieved in about 30-40 minutes and persisted for 5-6 hrs. In the beginning 3-4 applications were required but frequency decreased gradually as the pain abated.